American Oncology Institute (AOI) in Coimbatore Gives a New Lease of Life to 50-year-old Post-Menopausal Female with Carcinoma Vagina
Coimbatore, September 25, 2023 – American Oncology Institute (AOI) Coimbatore saved a 50-year-old female suffering from post-menopausal bleeding and vaginal discharge. The patient was diagnosed with carcinoma vagina, classified as clinical stage FIGO II. Despite being a known diabetic, her medical history included no significant pain, and she had near-normal bowel and bladder habits.
Upon examination, a palpable indurated growth involving the anterior wall of the upper and middle vagina was discovered. Subsequent biopsy results indicated moderate differentiated Squamous Cell Carcinoma. The PET-CT and additional blood investigations revealed soft tissue thickening involving the upper and mid-vagina, measuring 3.5cm in length and 1.5cm in thickness. However, there was no invasion into surrounding structures such as the bladder, urethra, or rectum, and lymph nodes were notably affected.
The treatment plan involved a comprehensive approach, combining radical radiation therapy, i.e., External Beam Radiation and Brachytherapy with concomitant chemotherapy. The treatment was administered using the TrueBeam STx LINAC at AOI Coimbatore, with meticulous planning to minimize radiation exposure to surrounding healthy tissues, particularly the bowel and rectum.
Dr C Anbu, Radiation Oncologist, American Oncology Institute, Coimbatore emphasized, "Carcinoma Vagina is a rare gynaecological malignancy. It accounts for less than 3% of all gynaecological malignancies. Squamous cell carcinoma accounts for almost 80% of vaginal cancer followed by adenocarcinoma. Like carcinoma cervix, infection with high-risk human papilloma virus infection (HPV type 16, 18) seems to be a major risk factor for development of vaginal cancer. In view of close proximity of vagina to structures like rectum bladder, radiation therapy helps in organ preservation when compared to surgery along with good tumor control and survival rates. Our patient's safety and well-being were paramount throughout the treatment process. By employing advanced techniques and delivering a radiation dose of 50.4 Gy in 28 fractions, we aimed to achieve the best possible outcomes with minimal side effects."
The patient exhibited excellent tolerance to the treatment, experiencing minimal acute radiation-induced side effects. One week after completing external beam radiation therapy, clinical evaluation revealed no significant indurated lesions, showcasing early positive responses. Subsequently, the patient received intracavitary image-guided vaginal cylinder brachytherapy for three sessions. During her first follow-up post-radiation therapy, she reported comfort and exhibited no major toxicity. Clinical examination indicated no evidence of disease.
Mr. Krishna Das, Zonal Director of AOI, Coimbatore, commented, "At AOI, we are dedicated to embracing technological advancements in our pursuit of precision cancer care. This remarkable success story underscores our commitment to providing cutting-edge treatments while prioritizing patient safety and comfort."
This case study emphasizes the effectiveness and safety of radiation therapy in treating carcinoma vagina, with a strong focus on organ preservation. It serves as a testament to AOI Coimbatore's dedication to delivering world-class oncological care.
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